Abstract 329: Simvastatin Inhibits TGF-β1-induced Proliferation and Activation of Cardiac Fibroblasts Through Inhibition of SMAD Pathway

Farhan Rizvi; Ramail Siddiqui; Alesandra DeFranco; Akhil Jayaprakash; Mahek Mirza; Larisa Emelyanova; Gracious Ross; Ekhson Hulmohamedov; Daniel O’Hair; A. Jamil Tajik; Arshad Jahangir

Abstract 329: Simvastatin Inhibits TGF-β1-induced Proliferation and Activation of Cardiac Fibroblasts Through Inhibition of SMAD Pathway

Farhan Rizvi, Ramail Siddiqui, Alesandra DeFranco, Akhil Jayaprakash, Mahek Mirza, Larisa Emelyanova, Gracious Ross, Ekhson Hulmohamedov, Daniel O’Hair, A. Jamil Tajik, Arshad Jahangir

Research output: Contribution to journal › Meeting abstract

Original language	American English
Journal	Circulation Research
Volume	115
Status	Published - Jul 18 2014

Disciplines

Biology
Biochemistry
Endocrinology
Immunology and Infectious Disease

Cite this

@article{51d7b9c0f2d347288dddd057fb3031bd,

title = "Abstract 329: Simvastatin Inhibits TGF-β1-induced Proliferation and Activation of Cardiac Fibroblasts Through Inhibition of SMAD Pathway",

author = "Farhan Rizvi and Ramail Siddiqui and Alesandra DeFranco and Akhil Jayaprakash and Mahek Mirza and Larisa Emelyanova and Gracious Ross and Ekhson Hulmohamedov and Daniel O{\textquoteright}Hair and Tajik, \{A. Jamil\} and Arshad Jahangir",

note = "Background: HMG-CoA reductase inhibitors (statins) have been shown to reduce the incidence of atrial fibrillation (AF) and its progression but the underlying mechanisms are not fully elucidated. Since atrial fibrosis plays a major role in the development of the substrate for AF progression, we hypothesized that statins antagonize the effect of profibrotic cytokines, reducing their stimulatory effect on fibroblast proliferation, differentiation and activation.",

year = "2014",

month = jul,

day = "18",

language = "American English",

volume = "115",

journal = "Circulation Research",

}

TY - JOUR

T1 - Abstract 329: Simvastatin Inhibits TGF-β1-induced Proliferation and Activation of Cardiac Fibroblasts Through Inhibition of SMAD Pathway

AU - Rizvi, Farhan

AU - Siddiqui, Ramail

AU - DeFranco, Alesandra

AU - Jayaprakash, Akhil

AU - Mirza, Mahek

AU - Emelyanova, Larisa

AU - Ross, Gracious

AU - Hulmohamedov, Ekhson

AU - O’Hair, Daniel

AU - Tajik, A. Jamil

AU - Jahangir, Arshad

N1 - Background: HMG-CoA reductase inhibitors (statins) have been shown to reduce the incidence of atrial fibrillation (AF) and its progression but the underlying mechanisms are not fully elucidated. Since atrial fibrosis plays a major role in the development of the substrate for AF progression, we hypothesized that statins antagonize the effect of profibrotic cytokines, reducing their stimulatory effect on fibroblast proliferation, differentiation and activation.

PY - 2014/7/18

Y1 - 2014/7/18

UR - http://circres.ahajournals.org/content/115/Suppl_1/A329

M3 - Meeting abstract

VL - 115

JO - Circulation Research

JF - Circulation Research

ER -

Abstract 329: Simvastatin Inhibits TGF-β1-induced Proliferation and Activation of Cardiac Fibroblasts Through Inhibition of SMAD Pathway

Disciplines

Other files and links

Cite this