INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma

Caitlin Costello; Faith E Davies; Gordon Cook; Jorge Vela-Ojeda; Jim Omel; Robert M Rifkin; Jesus Berdeja; Noemi Puig; Saad Z Usmani; Katja Weisel; Jeffrey A Zonder; Evangelos Terpos; Andrew Spencer; Xavier Leleu; Mario Boccadoro; Michael A Thompson; Dorothy Romanus; Dawn M Stull; Vania Hungria; Aurora Complex General Surgical Oncology Faculty

doi:10.2217/fon-2019-0013

INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma

Caitlin Costello, Faith E Davies, Gordon Cook, Jorge Vela-Ojeda, Jim Omel, Robert M Rifkin, Jesus Berdeja, Noemi Puig, Saad Z Usmani, Katja Weisel, Jeffrey A Zonder, Evangelos Terpos, Andrew Spencer, Xavier Leleu, Mario Boccadoro, Michael A Thompson, Dorothy Romanus, Dawn M Stull, Vania Hungria, Aurora Complex General Surgical Oncology Faculty

Advocate Aurora Health

Research output: Contribution to journal › Article › peer-review

Abstract

With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. Trial registration number: NCT02761187.

Original language	American English
Journal	Future Oncology
DOIs	https://doi.org/10.2217/fon-2019-0013
Status	Published - May 1 2019

Keywords

multiple myeloma
observational study
treatment

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Costello, C., Davies, F. E., Cook, G., Vela-Ojeda, J., Omel, J., Rifkin, R. M., Berdeja, J., Puig, N., Usmani, S. Z., Weisel, K., Zonder, J. A., Terpos, E., Spencer, A., Leleu, X., Boccadoro, M., Thompson, M. A., Romanus, D., Stull, D. M., Hungria, V., & Complex General Surgical Oncology Faculty, A. (2019). INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma. Future Oncology. https://doi.org/10.2217/fon-2019-0013

Costello, C, Davies, FE, Cook, G, Vela-Ojeda, J, Omel, J, Rifkin, RM, Berdeja, J, Puig, N, Usmani, SZ, Weisel, K, Zonder, JA, Terpos, E, Spencer, A, Leleu, X, Boccadoro, M, Thompson, MA, Romanus, D, Stull, DM, Hungria, V & Complex General Surgical Oncology Faculty, A 2019, 'INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma', Future Oncology. https://doi.org/10.2217/fon-2019-0013

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title = "INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma",

abstract = "With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. Trial registration number: NCT02761187.",

keywords = "multiple myeloma, observational study, treatment",

author = "Caitlin Costello and Davies, {Faith E} and Gordon Cook and Jorge Vela-Ojeda and Jim Omel and Rifkin, {Robert M} and Jesus Berdeja and Noemi Puig and Usmani, {Saad Z} and Katja Weisel and Zonder, {Jeffrey A} and Evangelos Terpos and Andrew Spencer and Xavier Leleu and Mario Boccadoro and Thompson, {Michael A} and Dorothy Romanus and Stull, {Dawn M} and Vania Hungria and {Complex General Surgical Oncology Faculty}, Aurora",

note = "Costello C, Davies FE, Cook G, et al. INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma. Future Oncol. 2019; 15(13):1411-1428. doi: 10.2217/fon-2019-0013.",

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T1 - INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma

AU - Costello, Caitlin

AU - Davies, Faith E

AU - Cook, Gordon

AU - Vela-Ojeda, Jorge

AU - Omel, Jim

AU - Rifkin, Robert M

AU - Berdeja, Jesus

AU - Puig, Noemi

AU - Usmani, Saad Z

AU - Weisel, Katja

AU - Zonder, Jeffrey A

AU - Terpos, Evangelos

AU - Spencer, Andrew

AU - Leleu, Xavier

AU - Boccadoro, Mario

AU - Thompson, Michael A

AU - Romanus, Dorothy

AU - Stull, Dawn M

AU - Hungria, Vania

AU - Complex General Surgical Oncology Faculty, Aurora

N1 - Costello C, Davies FE, Cook G, et al. INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma. Future Oncol. 2019; 15(13):1411-1428. doi: 10.2217/fon-2019-0013.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. Trial registration number: NCT02761187.

AB - With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. Trial registration number: NCT02761187.

KW - multiple myeloma

KW - observational study

KW - treatment

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UR - https://xk8bg6rv9a.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:30816809

U2 - 10.2217/fon-2019-0013

DO - 10.2217/fon-2019-0013

M3 - Article

JO - Future Oncology

JF - Future Oncology

ER -

INSIGHT MM: a large, global, prospective, non-interventional, real-world study of patients with multiple myeloma

Abstract

Keywords

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