Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus

Karima Addetia; Michael Henry; Heather Smith; Megan Yamat; Gene Kim; Renuka Jain; Eisha Wali; Linda Lee; Nathan Marzlin; AbdulRahman Abutaleb; Jonathan Crouch; Eric S. Weiss; Takeyoshi Ota; Christopher Salerno; Huihua Li; Aliya Husain; Valluvan Jeevanandam; Roberto M. Lang

doi:10.1016/j.amjcard.2025.04.016

Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus

Karima Addetia
, Michael Henry
, Heather Smith
, Megan Yamat
, Gene Kim
, Renuka Jain
, Eisha Wali
, Linda Lee
, Nathan Marzlin
, AbdulRahman Abutaleb
, Jonathan Crouch
, Eric S. Weiss
, Takeyoshi Ota
, Christopher Salerno
, Huihua Li
, Aliya Husain
, Valluvan Jeevanandam
, Roberto M. Lang

Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States. Electronic address: [email protected].
Department of Medicine, Section of Cardiology, University of Chicago Heart and Vascular Center, Chicago, IL, United States.

Research output: Contribution to journal › Article

Abstract

Cardiac implantable electronic devices (CIEDs) have been implicated in the development of tricuspid valve (TV) dysfunction. However, the mechanisms of dysfunction are not well characterized. We sought to define the prevalence, location and mechanisms of CIED-TV interference based on direct inspection of gross pathologic specimens from consecutive patients with CIEDs who had undergone orthotopic heart transplantation (OHT). CIED-interference was classified by location (septal, posterior or anterior trigone of the RV), portion of TV apparatus involved (leaflet(s) only, sub-tricuspid apparatus (STA) only or a combination of both leaflet and STA) and type of interference (adherence, trapping or both). Sixty-two cases of CIED-TV interference were identified (5 leaflet, 30 STA and 27 leaflet and STA). The majority of patients had non-ischemic cardiomyopathy (81%) and leads in situ for

Original language	American English
Journal	The American journal of cardiology
DOIs	https://doi.org/10.1016/j.amjcard.2025.04.016
Status	Published - Apr 23 2025

Access to Document

10.1016/j.amjcard.2025.04.016License: Unspecified

http://institutionalrepository.aah.org/auroragme/626

Cite this

Addetia, K., Henry, M., Smith, H., Yamat, M., Kim, G., Jain, R., Wali, E., Lee, L., Marzlin, N., Abutaleb, A., Crouch, J., Weiss, E. S., Ota, T., Salerno, C., Li, H., Husain, A., Jeevanandam, V., & Lang, R. M. (2025). Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus. The American journal of cardiology. https://doi.org/10.1016/j.amjcard.2025.04.016

Addetia, K, Henry, M, Smith, H, Yamat, M, Kim, G, Jain, R, Wali, E, Lee, L, Marzlin, N, Abutaleb, A, Crouch, J, Weiss, ES, Ota, T, Salerno, C, Li, H, Husain, A, Jeevanandam, V & Lang, RM 2025, 'Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus', The American journal of cardiology. https://doi.org/10.1016/j.amjcard.2025.04.016

@article{6b730f031e6446168beec3d244fd41b8,

title = "Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus",

abstract = "Cardiac implantable electronic devices (CIEDs) have been implicated in the development of tricuspid valve (TV) dysfunction. However, the mechanisms of dysfunction are not well characterized. We sought to define the prevalence, location and mechanisms of CIED-TV interference based on direct inspection of gross pathologic specimens from consecutive patients with CIEDs who had undergone orthotopic heart transplantation (OHT). CIED-interference was classified by location (septal, posterior or anterior trigone of the RV), portion of TV apparatus involved (leaflet(s) only, sub-tricuspid apparatus (STA) only or a combination of both leaflet and STA) and type of interference (adherence, trapping or both). Sixty-two cases of CIED-TV interference were identified (5 leaflet, 30 STA and 27 leaflet and STA). The majority of patients had non-ischemic cardiomyopathy (81\%) and leads in situ for ",

author = "Karima Addetia and Michael Henry and Heather Smith and Megan Yamat and Gene Kim and Renuka Jain and Eisha Wali and Linda Lee and Nathan Marzlin and AbdulRahman Abutaleb and Jonathan Crouch and Weiss, \{Eric S.\} and Takeyoshi Ota and Christopher Salerno and Huihua Li and Aliya Husain and Valluvan Jeevanandam and Lang, \{Roberto M.\}",

year = "2025",

month = apr,

day = "23",

doi = "10.1016/j.amjcard.2025.04.016",

language = "American English",

journal = "The American journal of cardiology",

}

TY - JOUR

T1 - Mechanisms of cardiac implantable electronic device interference with the tricuspid valve apparatus

AU - Addetia, Karima

AU - Henry, Michael

AU - Smith, Heather

AU - Yamat, Megan

AU - Kim, Gene

AU - Jain, Renuka

AU - Wali, Eisha

AU - Lee, Linda

AU - Marzlin, Nathan

AU - Abutaleb, AbdulRahman

AU - Crouch, Jonathan

AU - Weiss, Eric S.

AU - Ota, Takeyoshi

AU - Salerno, Christopher

AU - Li, Huihua

AU - Husain, Aliya

AU - Jeevanandam, Valluvan

AU - Lang, Roberto M.

PY - 2025/4/23

Y1 - 2025/4/23

N2 - Cardiac implantable electronic devices (CIEDs) have been implicated in the development of tricuspid valve (TV) dysfunction. However, the mechanisms of dysfunction are not well characterized. We sought to define the prevalence, location and mechanisms of CIED-TV interference based on direct inspection of gross pathologic specimens from consecutive patients with CIEDs who had undergone orthotopic heart transplantation (OHT). CIED-interference was classified by location (septal, posterior or anterior trigone of the RV), portion of TV apparatus involved (leaflet(s) only, sub-tricuspid apparatus (STA) only or a combination of both leaflet and STA) and type of interference (adherence, trapping or both). Sixty-two cases of CIED-TV interference were identified (5 leaflet, 30 STA and 27 leaflet and STA). The majority of patients had non-ischemic cardiomyopathy (81%) and leads in situ for

AB - Cardiac implantable electronic devices (CIEDs) have been implicated in the development of tricuspid valve (TV) dysfunction. However, the mechanisms of dysfunction are not well characterized. We sought to define the prevalence, location and mechanisms of CIED-TV interference based on direct inspection of gross pathologic specimens from consecutive patients with CIEDs who had undergone orthotopic heart transplantation (OHT). CIED-interference was classified by location (septal, posterior or anterior trigone of the RV), portion of TV apparatus involved (leaflet(s) only, sub-tricuspid apparatus (STA) only or a combination of both leaflet and STA) and type of interference (adherence, trapping or both). Sixty-two cases of CIED-TV interference were identified (5 leaflet, 30 STA and 27 leaflet and STA). The majority of patients had non-ischemic cardiomyopathy (81%) and leads in situ for

U2 - 10.1016/j.amjcard.2025.04.016

DO - 10.1016/j.amjcard.2025.04.016

M3 - Article

C2 - 40280194

JO - The American journal of cardiology

JF - The American journal of cardiology

ER -