Stress-induced changes in immune signatures in ME/CFS patients determined by transcriptome analysis

Jackson Gamer; Derek Van Booven; Oskar Zarnowski; Melanie Perez; Joshua Frank; Rajendra P. Pangeni; Fanny Collado; Nancy G. Klimas; Elisa Oltra; Lubov Nathanson

doi:10.1007/978-1-0716-4498-0_7

Stress-induced changes in immune signatures in ME/CFS patients determined by transcriptome analysis

Jackson Gamer
, Derek Van Booven
, Oskar Zarnowski
, Melanie Perez
, Joshua Frank
, Rajendra P. Pangeni
, Fanny Collado
, Nancy G. Klimas
, Elisa Oltra
, Lubov Nathanson

Institute for Neuro Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
Dr. J.P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Department of Emergency Medicine, University of Texas Southwestern, Dallas, TX, USA.
School Medicine, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.
Institute for Neuro Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA. [email protected].

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional malaise (PEM). We evaluated transcriptomic changes in peripheral blood mononuclear cells (PBMC) of ME/CFS patients undergoing an exercise challenge and explored the transcriptomic response to exercise and recovery in PBMC of ME/CFS patients, as compared to healthy controls using RNA sequencing technology. As transcriptomic changes in ME/CFS patients are still in the phase of discovery, analysis of data has to be stringent, and the most important results have to be validated by a different technology, such as real-time PCR or NanoString.

Original language	American English
Title of host publication	Advocate GME
DOIs	https://doi.org/10.1007/978-1-0716-4498-0_7
Status	Published - Jan 1 2025

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10.1007/978-1-0716-4498-0_7License: Unspecified

http://institutionalrepository.aah.org/advocategme/1221

Cite this

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title = "Stress-induced changes in immune signatures in ME/CFS patients determined by transcriptome analysis",

abstract = "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional malaise (PEM). We evaluated transcriptomic changes in peripheral blood mononuclear cells (PBMC) of ME/CFS patients undergoing an exercise challenge and explored the transcriptomic response to exercise and recovery in PBMC of ME/CFS patients, as compared to healthy controls using RNA sequencing technology. As transcriptomic changes in ME/CFS patients are still in the phase of discovery, analysis of data has to be stringent, and the most important results have to be validated by a different technology, such as real-time PCR or NanoString.",

author = "Jackson Gamer and Booven, \{Derek Van\} and Oskar Zarnowski and Melanie Perez and Joshua Frank and Pangeni, \{Rajendra P.\} and Fanny Collado and Klimas, \{Nancy G.\} and Elisa Oltra and Lubov Nathanson",

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T1 - Stress-induced changes in immune signatures in ME/CFS patients determined by transcriptome analysis

AU - Gamer, Jackson

AU - Booven, Derek Van

AU - Zarnowski, Oskar

AU - Perez, Melanie

AU - Frank, Joshua

AU - Pangeni, Rajendra P.

AU - Collado, Fanny

AU - Klimas, Nancy G.

AU - Oltra, Elisa

AU - Nathanson, Lubov

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional malaise (PEM). We evaluated transcriptomic changes in peripheral blood mononuclear cells (PBMC) of ME/CFS patients undergoing an exercise challenge and explored the transcriptomic response to exercise and recovery in PBMC of ME/CFS patients, as compared to healthy controls using RNA sequencing technology. As transcriptomic changes in ME/CFS patients are still in the phase of discovery, analysis of data has to be stringent, and the most important results have to be validated by a different technology, such as real-time PCR or NanoString.

AB - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional malaise (PEM). We evaluated transcriptomic changes in peripheral blood mononuclear cells (PBMC) of ME/CFS patients undergoing an exercise challenge and explored the transcriptomic response to exercise and recovery in PBMC of ME/CFS patients, as compared to healthy controls using RNA sequencing technology. As transcriptomic changes in ME/CFS patients are still in the phase of discovery, analysis of data has to be stringent, and the most important results have to be validated by a different technology, such as real-time PCR or NanoString.

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DO - 10.1007/978-1-0716-4498-0_7

M3 - Chapter

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BT - Advocate GME

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